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Sequence Transpositions Restore Genes on the HighlyDegenerated W Chromosomes of Songbirds
Naturhistoriska riksmuseet, Enheten för bioinformatik och genetik.ORCID-id: 0000-0003-1680-6861
2020 (Engelska)Ingår i: Genes, E-ISSN 2073-4425, Vol. 11, artikel-id 1267Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The female-specific W chromosomes of most Neognathae birds are highly degenerated and gene-poor. Previous studies have demonstrated that the gene repertoires of the Neognathae bird W chromosomes, despite being in small numbers, are conserved across bird species, likely due to purifying selection maintaining the regulatory and dosage-sensitive genes. Here we report the discovery of DNA-based sequence duplications from the Z to the W chromosome in birds-of-paradise (Paradisaeidae, Passeriformes), through sequence transposition. The original transposition involved nine genes, but only two of them (ANXA1 and ALDH1A1) survived on the W chromosomes. Both ANXA1 and ALDH1A1 are predicted to be dosage-sensitive, and the expression of ANXA1 is restricted to ovaries in all the investigated birds. These analyses suggest the newly transposed gene onto the W chromosomes can be favored for their role in restoring dosage imbalance or through female-specific selection. After examining seven additional songbird genomes, we further identified five other transposed genes on the W chromosomes of Darwin’s finches and one in the great tit, expanding the observation of the Z-to-W transpositions to a larger range of bird species, but not all transposed genes exhibit dosage-sensitivity or ovary-biased expression We demonstrate a new mechanism by which the highly degenerated W chromosomes of songbirds can acquire genes from the homologous Z chromosomes, but further functional investigations are needed to validate the evolutionary forces underlying the transpositions

Ort, förlag, år, upplaga, sidor
2020. Vol. 11, artikel-id 1267
Nationell ämneskategori
Naturvetenskap
Forskningsämne
Ekosystem och arthistoria
Identifikatorer
URN: urn:nbn:se:nrm:diva-4077OAI: oai:DiVA.org:nrm-4077DiVA, id: diva2:1511315
Forskningsfinansiär
Vetenskapsrådet, 621-2014-5113Tillgänglig från: 2020-12-18 Skapad: 2020-12-18 Senast uppdaterad: 2024-07-04Bibliografiskt granskad

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https://doi.org/10.3390/genes11111267

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