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A Combined Transcriptomics and Proteomics Approach Reveals the Differences in the Predatory and Defensive Venoms of the Molluscivorous Cone Snail Cylinder ammiralis (Caenogastropoda: Conidae)
Swedish Museum of Natural History, Department of Zoology. (Ulf Jondelius)ORCID iD: 0000-0001-7790-0603
IBMM, Université de Montpellier CNRS.ORCID iD: 0000-0002-2945-1484
Museo Nacional de Ciencias Naturales.ORCID iD: 0000-0001-6212-9502
2021 (English)In: Toxins, ISSN 2072-6651, E-ISSN 2072-6651, Vol. 13, no 9, p. 642-642Article in journal (Refereed) Published
Abstract [en]

Venoms are complex mixtures of proteins that have evolved repeatedly in the animal kingdom. Cone snail venoms represent one of the best studied venom systems. In nature, this venom can be dynamically adjusted depending on its final purpose, whether to deter predators or hunt prey. Here, the transcriptome of the venom gland and the proteomes of the predation-evoked and defensive venoms of the molluscivorous cone snail Cylinder ammiralis were catalogued. A total of 242 venom-related transcripts were annotated. The conotoxin superfamilies presenting more different peptides were O1, O2, T, and M, which also showed high expression levels (except T). The three precursors of the J superfamily were also highly expressed. The predation-evoked and defensive venoms showed a markedly distinct profile. A total of 217 different peptides were identified, with half of them being unique to one venom. A total of 59 peptides ascribed to 23 different protein families were found to be exclusive to the predatory venom, including the cono-insulin, which was, for the first time, identified in an injected venom. A total of 43 peptides from 20 protein families were exclusive to the defensive venom. Finally, comparisons of the relative abundance (in terms of number of peptides) of the different conotoxin precursor superfamilies showed that most of them present similar abundance regardless of the diet.

Place, publisher, year, edition, pages
2021. Vol. 13, no 9, p. 642-642
Keywords [en]
Conidae; transcriptome; proteome; conotoxin; cono-insulin; Cylinder ammiralis
National Category
Evolutionary Biology Zoology
Research subject
Diversity of life
Identifiers
URN: urn:nbn:se:nrm:diva-4261DOI: 10.3390/toxins13090642OAI: oai:DiVA.org:nrm-4261DiVA, id: diva2:1600543
Available from: 2021-10-05 Created: 2021-10-05 Last updated: 2021-10-14Bibliographically approved

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Abalde, SamuelDutertre, SébastienZardoya, Rafael
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