Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Changes in variation at the MHC class II DQA locus during the final demise of the woolly mammoth.
Swedish Museum of Natural History, Department of Bioinformatics and Genetics.
2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6Article in journal (Refereed) Published
Abstract [en]

According to the nearly-neutral theory of evolution, the relative strengths of selection and drift shift in favour of drift at small population sizes. Numerous studies have analysed the effect of bottlenecks and small population sizes on genetic diversity in the MHC, which plays a central role in pathogen recognition and immune defense and is thus considered a model example for the study of adaptive evolution. However, to understand changes in genetic diversity at loci under selection, it is necessary to compare the genetic diversity of a population before and after the bottleneck. In this study, we analyse three fragments of the MHC DQA gene in woolly mammoth samples radiocarbon dated to before and after a well-documented bottleneck that took place about ten thousand years ago. Our results indicate a decrease in observed heterozygosity and number of alleles, suggesting that genetic drift had an impact on the variation on MHC. Based on coalescent simulations, we found no evidence of balancing selection maintaining MHC diversity during the Holocene. However, strong trans-species polymorphism among mammoths and elephants points to historical effects of balancing selection on the woolly mammoth lineage.

Place, publisher, year, edition, pages
2016. Vol. 6
National Category
Genetics
Research subject
Diversity of life
Identifiers
URN: urn:nbn:se:nrm:diva-1995DOI: 10.1038/srep25274PubMedID: 27143688OAI: oai:DiVA.org:nrm-1995DiVA: diva2:1052181
Funder
Swedish Research Council, 2012-3869
Available from: 2016-12-05 Created: 2016-12-05 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

fulltext(1166 kB)21 downloads
File information
File name FULLTEXT01.pdfFile size 1166 kBChecksum SHA-512
6aa0ddea7a8e09cd5c83e9dd73ddfd1bb7f128773776a56a1a8d4202fbc2babd127d67a400132ded08edb4acb4fca10d33fd6e5618c8138143ff650e979ce2a2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pečnerová, PatríciaDíez-Del-Molino, DavidDalén, Love
By organisation
Department of Bioinformatics and Genetics
In the same journal
Scientific Reports
Genetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 21 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf