Mapping the age and trace element and Sm-Nd isotope compositions of monazite grains from a peraluminous Cretaceous granite using laser ablation–split stream analysis reveals a wide range in Nd isotope and rare earth element (REE) compositions within and between single grains. These data corroborate isotopic variability indicated by Hf isotope analysis of zircon in the same granite sample. The REE variations indicate that monazite grew during fractional crystallization. Hf and Nd isotopes indicate that the granitic magma was generated from at least two distinct Proterozoic sources of approximately the same age: one component that had highly radiogenic initial 176Hf/177Hf and 143Nd/144Nd and a second component that was notably less radiogenic. This study highlights the utility of in situ REE and Sm-Nd isotope data in monazite in magmatic systems. Further, it refines the zircon-based constraints on magmatic processes because of sensitivity of light REEs to fractional crystallization, lower probability of complications owing to inheritance, and smaller analytical volumes required.