Livers of caribou and reindeer (Rangifer tarandus) from Canada (n = 146), Greenland (n = 30), Svalbard (n = 7), and Sweden(n = 60) were analyzed for concentrations of eight perfluoroalkyl carboxylic acids and four perfluoroalkane sulfonic acids. InCanadian caribou, PFNA (range < 0.01–7.4 ng/g wet weight, ww) and PFUnDA (<0.01–5.6 ng/g ww) dominated, whereasPFOS predominated in samples from South Greenland, Svalbard, and Sweden, although the highest concentrations were found incaribou from Southwest Greenland (up to 28 ng/g ww). We found the highest median concentrations of all PFAS except PFHxSin Akia-Maniitsoq caribou (Southwest Greenland, PFOS 7.2–19 ng/g ww, median 15 ng/g ww). The highest concentrations ofΣPFAS were also found in Akia-Maniitoq caribou (101 ng/g ww) followed by the nearby Kangerlussuaq caribou (45 ng/g ww),where the largest airport in Greenland is situated, along with a former military base. Decreasing trends in concentrations wereseen for PFOS in the one Canadian and three Swedish populations. Furthermore, PFNA, PFDA, PFUnDA, PFDoDA, andPFTrDA showed decreasing trends in Canada’s Porcupine caribou between 2005 and 2016. In Sweden, PFHxS increased inthe reindeer from Norrbotten between 2003 and 2011. The reindeer from Västerbotten had higher concentrations of PFNA andlower concentrations of PFHxS in 2010 compared to 2002. Finally, we observed higher concentrations in 2010 compared to 2002(albeit statistically insignificant) for PFHxS in Jämtland, while PFNA, PFDA, PFUnDA, PFDoDA, and PFTrDA showed nodifference at all.