Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears
Show others and affiliations
2014 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 157, no 4, 785-794 p.Article in journal (Refereed) Published
Abstract [en]

Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyper-lipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans.

Place, publisher, year, edition, pages
2014. Vol. 157, no 4, 785-794 p.
National Category
Zoology
Research subject
Ecosystems and species history
Identifiers
URN: urn:nbn:se:nrm:diva-1066DOI: 10.1016/j.cell.2014.03.054OAI: oai:DiVA.org:nrm-1066DiVA: diva2:773611
Funder
Swedish Research Council, 621-2008-4896EU, European Research Council
Available from: 2014-12-19 Created: 2014-12-19 Last updated: 2014-12-19Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Dalén, Love

Search in DiVA

By author/editor
Dalén, Love
By organisation
Department of Bioinformatics and Genetics
In the same journal
Cell
Zoology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 70 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf