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Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.ORCID iD: 0000-0002-3072-4929
Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden;Pelago Bioscience, SE-171 48 Solna, Sweden.ORCID iD: 0000-0001-7709-0161
Department of Archaeology and Classical Studies, Stockholm University, SE-114 19 Stockholm, Sweden.
Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden;Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID iD: 0000-0002-2639-6328
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2022 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 144, no 6, p. 2484-2487Article in journal (Refereed) Published
Abstract [en]

Analyzing the δ2H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found insome samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than inseawater. This corresponds to at least 4 times higher δ2H than in any previously reported biogenic sample. We ruled out diet as aplausible mechanism for such anomalous enrichment. This finding puts into question the old adage that “you are what you eat”.

Place, publisher, year, edition, pages
2022. Vol. 144, no 6, p. 2484-2487
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Biochemistry and Molecular Biology
Research subject
Ecosystems and species history
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URN: urn:nbn:se:nrm:diva-4979DOI: 10.1021/jacs.1c12512OAI: oai:DiVA.org:nrm-4979DiVA, id: diva2:1717529
Funder
Swedish Research Council, 2017-04303Swedish Research Council, 2020-00687Swedish Society of Medicine, 1086Swedish Society of Medicine, SLS-961262Available from: 2022-12-08 Created: 2022-12-08 Last updated: 2022-12-09Bibliographically approved

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